# Arthur Goldsipe

### MathWorks

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**Feeds**

how to handle the error 'Levenberg-Marquardt algorithm the Jacobian at BETA0 is ill-conditioned'?

It's difficult to say exactly what's going on without seeing your model and data. One explanation is that your model is not appr...

7 dagar ago | 0

How to write code for repetitive process?

If I understand your question, you're asking how to create an event that fires repeatedly. I'm not sure exactly what kind of rep...

7 dagar ago | 0

Investigating the effect of two covariates to an estimated parameter

Yes, you can specify multiple covariates. An example covariate expresssion would be exp(theta_fixed + theta1*covariate1 + theta2...

10 dagar ago | 0

| accepted

Why are population estimated parameters values the same as individual estimated parameters values?

Without the actual project, it's difficult to say what's going on. So let me offer some potential explanations for what you're s...

10 dagar ago | 0

How to simulate a drug concentration-time curve with confidence intervals?

Where did this plot come from? Without more information, we won't be able to say exactly how it was created. However, it looks ...

17 dagar ago | 0

| accepted

Oral Dose Not Exhibiting Absorption/Bioavailability in Simulation

Copying the answer from the comments: "Just wanted to update that I figured out a solution to the problem! I ended up creating a...

ungefär 2 månader ago | 0

Simbiology Previous Initial Parameters

The results of a fit only contain the outputs of the fit itself (for example, parameter estimates). If you want to reproduce tho...

2 månader ago | 0

Transfer parameter estimates to model

For item #1, the SimBiologyModelAnalyzer app allows you to create a variant of the parameter estimates (see here for more detail...

3 månader ago | 2

| accepted

Encoding conditional assignments in SimBiology

Hi emjey, I see this problem solved in one of two ways: 1) Take advantage of true/false getting converted to 1/0 in mathematic...

3 månader ago | 1

How do I fit multiple curves at once, sharing some fitting parameters and floating others?

Are the 6 different analyte concentrations something you want to specify or estimate? Both of these these are possible in SimBio...

3 månader ago | 1

| accepted

Different dilution effect on the kinetics of a time course

Hi Luis, Because you don't use units in your model, SimBiology interprets the reaction rates to have dimensions of amount/time....

4 månader ago | 0

| accepted

Question re/ matlab.codetools.requiredFilesAndProducts function.

I'd first check the "Certain" field of the pList output to see if these products have been marked as definitely or just possibly...

4 månader ago | 0

changes the the simulated mass with changing the absolute and relative tolerance

First, a disclaimer. I'm a SimBiology developer, not a modeler. So I'm most knowledgable about what is technically possible with...

4 månader ago | 0

different event functions for the same species

The problem is that you have two conflicting mathematical definitions of Fw. You are trying to set it with both a repeated assig...

5 månader ago | 0

| accepted

How do I fix a duplicate name error ?

It's hard to know exactly what's going on without more details. Can you share more details? Ideally, can you share the project a...

5 månader ago | 0

| accepted

A variable is specified by more than one assignment rule

It sounds like you have an ill-defined problem with an algebraic loop. Specifically, A_Total is a function of a, but a is a func...

6 månader ago | 0

Data fit to observables

Hi Justine, I just tried this in R2023b, and I was able to select an observable in the mapping for the response. I'm attaching ...

6 månader ago | 0

| accepted

Fitting model on a Debian machine

If you want to fit a SimBiology model using a command-line function, you can directly call sbiofit (or sbiofitmixed). This is ex...

6 månader ago | 0

Modeling Mitochondria Voltage depending on the Sodium/Potassium Pumps results in Algebraic loops Error.

Can you share your model? That would allow me to offer more specific advice. (If you're not comfortable posting it publicly, ple...

6 månader ago | 0

| accepted

How can I add stoichiometry value in simbiology model builder 2023b ?

I believe your question is similar to this one. Please see the accepted answer there.

6 månader ago | 0

| accepted

Dimensional analysis issue because of the function 'log' in the rule

Since your expression is dimensionally correct, you can safely ignore this warning. Note that is an informational warning (as o...

7 månader ago | 0

| accepted

Using simFunction Object in Simbiology when my stoichiometry depends on a model parameter

The error you report is intended to communicate that SimBiology does not allow the following the following combination of condit...

7 månader ago | 0

| accepted

Sensitivity analysis in Simbiology

SimBiology does not currently support local sensitivity analysis on models with active events. One potential workaround is to pe...

9 månader ago | 0

Apply fmincon nonlinear parameter inequality constraints into SimBiology for parameterization

The estimation program in the SimBiology Model Analyzer app uses the command-line function sbiofit. Unfortunately, this function...

10 månader ago | 0

| accepted

Parameter unit setting problem

Hi Bohao, SimBiology's units functionality does not support embedding numeric multipliers like 10^15. And even after you addres...

10 månader ago | 0

| accepted

Categorical covariates in parameter estimation

Do you want to do nonlinear regression or nonlinear mixed effects (NLME)? The feature Joe mentions in his comment only applies t...

11 månader ago | 0

| accepted

How to solve this error

(Copying answer from comments.) The problem was that one value of DV1 was 0, so the resulting weight was infinite. One thing I ...

11 månader ago | 0

Fit simbiology model to cmax or AUC data

One option would be to add Cmax to your model as an observable. Then, you can include Cmax in your fit the same way you fit to a...

12 månader ago | 3

Change in simulation output with changing in the units of stop time

If you have constructed your model correctly, I expect the results of the two simulations to be equivalent but not numerically i...

ungefär ett år ago | 0

| accepted

Failure of dimensional analysis for a rule

When you enable dimensional analysis (or unit conversion) in SimBiology, fractional exponents can only be applied to dimensionle...

ungefär ett år ago | 0

| accepted