Arthur Goldsipe

MathWorks

Last seen: 4 dagar ago | Active since 2011

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Answered
how to handle the error 'Levenberg-Marquardt algorithm the Jacobian at BETA0 is ill-conditioned'?
It's difficult to say exactly what's going on without seeing your model and data. One explanation is that your model is not appr...

7 dagar ago | 0

Answered
How to write code for repetitive process?
If I understand your question, you're asking how to create an event that fires repeatedly. I'm not sure exactly what kind of rep...

7 dagar ago | 0

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Investigating the effect of two covariates to an estimated parameter
Yes, you can specify multiple covariates. An example covariate expresssion would be exp(theta_fixed + theta1*covariate1 + theta2...

10 dagar ago | 0

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Answered
Why are population estimated parameters values the same as individual estimated parameters values?
Without the actual project, it's difficult to say what's going on. So let me offer some potential explanations for what you're s...

10 dagar ago | 0

Answered
How to simulate a drug concentration-time curve with confidence intervals?
Where did this plot come from? Without more information, we won't be able to say exactly how it was created. However, it looks ...

17 dagar ago | 0

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Answered
Oral Dose Not Exhibiting Absorption/Bioavailability in Simulation
Copying the answer from the comments: "Just wanted to update that I figured out a solution to the problem! I ended up creating a...

ungefär 2 månader ago | 0

Answered
Simbiology Previous Initial Parameters
The results of a fit only contain the outputs of the fit itself (for example, parameter estimates). If you want to reproduce tho...

2 månader ago | 0

Answered
Transfer parameter estimates to model
For item #1, the SimBiologyModelAnalyzer app allows you to create a variant of the parameter estimates (see here for more detail...

3 månader ago | 2

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Answered
Encoding conditional assignments in SimBiology
Hi emjey, I see this problem solved in one of two ways: 1) Take advantage of true/false getting converted to 1/0 in mathematic...

3 månader ago | 1

Answered
How do I fit multiple curves at once, sharing some fitting parameters and floating others?
Are the 6 different analyte concentrations something you want to specify or estimate? Both of these these are possible in SimBio...

3 månader ago | 1

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Answered
Different dilution effect on the kinetics of a time course
Hi Luis, Because you don't use units in your model, SimBiology interprets the reaction rates to have dimensions of amount/time....

4 månader ago | 0

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Answered
Question re/ matlab.codetools.requiredFilesAndProducts function.
I'd first check the "Certain" field of the pList output to see if these products have been marked as definitely or just possibly...

4 månader ago | 0

Answered
changes the the simulated mass with changing the absolute and relative tolerance
First, a disclaimer. I'm a SimBiology developer, not a modeler. So I'm most knowledgable about what is technically possible with...

4 månader ago | 0

Answered
different event functions for the same species
The problem is that you have two conflicting mathematical definitions of Fw. You are trying to set it with both a repeated assig...

5 månader ago | 0

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Answered
How do I fix a duplicate name error ?
It's hard to know exactly what's going on without more details. Can you share more details? Ideally, can you share the project a...

5 månader ago | 0

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Answered
A variable is specified by more than one assignment rule
It sounds like you have an ill-defined problem with an algebraic loop. Specifically, A_Total is a function of a, but a is a func...

6 månader ago | 0

Answered
Data fit to observables
Hi Justine, I just tried this in R2023b, and I was able to select an observable in the mapping for the response. I'm attaching ...

6 månader ago | 0

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Answered
Fitting model on a Debian machine
If you want to fit a SimBiology model using a command-line function, you can directly call sbiofit (or sbiofitmixed). This is ex...

6 månader ago | 0

Answered
Modeling Mitochondria Voltage depending on the Sodium/Potassium Pumps results in Algebraic loops Error.
Can you share your model? That would allow me to offer more specific advice. (If you're not comfortable posting it publicly, ple...

6 månader ago | 0

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Answered
How can I add stoichiometry value in simbiology model builder 2023b ?
I believe your question is similar to this one. Please see the accepted answer there.

6 månader ago | 0

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Answered
Dimensional analysis issue because of the function 'log' in the rule
Since your expression is dimensionally correct, you can safely ignore this warning. Note that is an informational warning (as o...

7 månader ago | 0

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Answered
Using simFunction Object in Simbiology when my stoichiometry depends on a model parameter
The error you report is intended to communicate that SimBiology does not allow the following the following combination of condit...

7 månader ago | 0

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Answered
Sensitivity analysis in Simbiology
SimBiology does not currently support local sensitivity analysis on models with active events. One potential workaround is to pe...

9 månader ago | 0

Answered
Apply fmincon nonlinear parameter inequality constraints into SimBiology for parameterization
The estimation program in the SimBiology Model Analyzer app uses the command-line function sbiofit. Unfortunately, this function...

10 månader ago | 0

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Answered
Parameter unit setting problem
Hi Bohao, SimBiology's units functionality does not support embedding numeric multipliers like 10^15. And even after you addres...

10 månader ago | 0

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Answered
Categorical covariates in parameter estimation
Do you want to do nonlinear regression or nonlinear mixed effects (NLME)? The feature Joe mentions in his comment only applies t...

11 månader ago | 0

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Answered
How to solve this error
(Copying answer from comments.) The problem was that one value of DV1 was 0, so the resulting weight was infinite. One thing I ...

11 månader ago | 0

Answered
Fit simbiology model to cmax or AUC data
One option would be to add Cmax to your model as an observable. Then, you can include Cmax in your fit the same way you fit to a...

12 månader ago | 3

Answered
Change in simulation output with changing in the units of stop time
If you have constructed your model correctly, I expect the results of the two simulations to be equivalent but not numerically i...

ungefär ett år ago | 0

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Answered
Failure of dimensional analysis for a rule
When you enable dimensional analysis (or unit conversion) in SimBiology, fractional exponents can only be applied to dimensionle...

ungefär ett år ago | 0

| accepted