It is.
First, take the Fourier transform of your signal to see the frequency components. See the documentation for fft for guidance.
Second, you need to design your filter pass-band and stop-band frequencies using the information from your Fourier transform, and then implement your filter. You need the Signal Processing Toolbox to do it. There are several ways to design filters. My filter design procedure is here: How to design a lowpass filter for ocean wave data in Matlab?
