Getting Started Using the SimBiology Apps

SimBiology provides a set of integrated apps that are designed to facilitate building, simulating, and analyzing models of dynamic systems such as pharmacokinetic/pharmacodynamic (PK/PD) and mechanistic systems biology models.

• The SimBiology Model Builder app lets you build dynamic models interactively using various modeling elements. For instance, you can model a variety of biological systems such as signaling pathways, metabolic networks, and PK/PD models. It also lets you model biological variability and different dosing regimens to investigate various experimental conditions and dosing strategies.

• The SimBiology Model Analyzer app lets you perform analyses on models of dynamic systems. You can simulate the dynamic behavior of a model using various solvers and estimate model parameters. To investigate system dynamics and guide experimentation, you can perform sensitivity analysis and parameter sweeps.

See the following tutorials to get started.

Build Models

• Create Model of Receptor-Ligand Kinetics

• Incorporate SGLT2 Inhibition into Physiologically Based Glucose-Insulin Model Using SimBiology Model Builder

• Undo and Redo Model Changes in SimBiology

• Copy SimBiology Blocks

• Keyboard Shortcuts for SimBiology Model Builder

• SimBiology Model Component Libraries

• Message Indicator Icons in SimBiology Model Builder

Analyze Models and Data

• Calculate NCA Parameters and Fit Model to PK/PD Data Using SimBiology Model Analyzer

• Find Important Tumor Growth Parameters with Local Sensitivity Analysis Using SimBiology Model Analyzer

• Explore Biological Variability with Virtual Patients Using SimBiology Model Analyzer

• Scan Dosing Regimens Using SimBiology Model Analyzer App