TREMBLE and TEM analysis

Version 1.0.0 (4.24 MB) by Jenny
Quantification of ligand binding with positron emission tomography (PET)
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Updated 6 Feb 2019

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True equilibrium bolus estimation (TREMBLE) and transient equilibrium bolus estimation (TEM) are two kinetic models that offer quantification of PET ligand binding at transient equilibrium. This GUI enables user-friendly analysis using time-activity curves from brain and plasma as input and computes bound ligand quantity and BP_ND as outcome.

References to the models:
Wong, D., Sølling, T., Yokoi, F. & Gjedde, A. Quantification of extracellular dopamine release in schizophrenia and
cocaine use by means of TREMBLE. Quant. Funct. Brain Imaging with Positron Emiss. Tomogr. 463–468 (1998).

Farde, L. et al. D2 dopamine receptors in neuroleptic-naive schizophrenic patients: a positron emission tomography study with [11C] raclopride. Arch. Gen. Psychiatry 47, 213–219 (1990).

Cite As

Jenny (2024). TREMBLE and TEM analysis (https://www.mathworks.com/matlabcentral/fileexchange/70208-tremble-and-tem-analysis), MATLAB Central File Exchange. Retrieved .

MATLAB Release Compatibility
Created with R2018b
Compatible with any release
Platform Compatibility
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Version Published Release Notes
1.0.0