Volume change in simbiology
3 views (last 30 days)
Show older comments
Ardeshir Goliaei
on 21 Aug 2019
Answered: Arthur Goldsipe
on 22 Aug 2019
I have a question about how Simbiology handles volume changes during a simulation. I understand that by assigning ConstantCapacity to false we can allow the capacity of a compartment to change according to some rule; as an example, a tumor compartment that responds to drug treatment. But how does Simbiology handle the concentration of species that reside in this compartment? If tumor is shrinking, the concentration of species within it will increase, which is an artefact.
Any comment would be greatly appreciate.
0 Comments
Accepted Answer
Arthur Goldsipe
on 22 Aug 2019
As described here, SimBiology conserves amounts when changing compartment volumes. If I were building the model, I would not use SimBiology's compartment volume to track the tumor volume. Instead, I would track tumor volume in a "non-constant SimBiology parameter" and set me SimBiology compartment volume to some standard reference volume (e.g., 1 milliliter).
I already logged an enhancement request in our database to allow conservation of concentrations instead of amounts. I'll make sure to add this use case to the request.
-Arthur
0 Comments
More Answers (0)
Communities
More Answers in the SimBiology Community
See Also
Categories
Find more on Scan Parameter Ranges in Help Center and File Exchange
Products
Community Treasure Hunt
Find the treasures in MATLAB Central and discover how the community can help you!
Start Hunting!