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How to determine parameters in co-variance matrix in linear mixed effect model?

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I have a mixed effect model of : Y=Xa+Zb; where b is my random coefficient. I have multiple groups. SO, b~multivariate normal(0,C); error~N(0,sigma^2I) . I want to model my C=[a1 a2 a3;a4 ...;...an]* K(f(l1,l2.....ln)). My question is how can I compute these parameters a1,a2...;l1,l2.....,ln in linear mixed effect model by fitlme/ fitlmematrix / fitrgp/dacekrigging?

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