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Calculate Sensitivities

Determine which model components are sensitive to specific conditions or drugs

Functions

`sbioelementaryeffects`	Perform global sensitivity analysis (GSA) by computing elementary effects (requires Statistics and Machine Learning Toolbox)
`sbiosobol`	Perform global sensitivity analysis by computing first- and total-order Sobol indices (requires Statistics and Machine Learning Toolbox)
`sbiompgsa`	Perform multiparametric global sensitivity analysis (requires Statistics and Machine Learning Toolbox)
`sbiosimulate`	Simulate SimBiology model
`sbioaccelerate`	Prepare model object for accelerated simulations
`createSimFunction`	Create SimFunction object
`sbiosampleparameters`	Generate parameters by sampling covariate model (requires Statistics and Machine Learning Toolbox software)
`sbiosampleerror`	Sample error based on error model and add noise to simulation data
`addconfigset`	Create configuration set object and add to model object
`getconfigset`	Get configuration set object from model object
`getsensmatrix (SimData)`	Get 3-D sensitivity matrix from `SimData` object

Objects

`SimBiology.gsa.ElementaryEffects`	Object containing results from calculation of elementary effects for global sensitivity analysis (GSA)
`SimBiology.gsa.Sobol`	Object containing first- and total-order Sobol indices
`SimBiology.gsa.MPGSA`	Object containing multiparametric global sensitivity analysis (MPGSA) results
`SensitivityAnalysisOptions`	Specify sensitivity analysis options
`SimData`	Simulation data
`Configset`	Solver settings information for model simulation
`SolverOptions`	Specify model solver options
`RuntimeOptions`	Options for logged species
`CompileOptions`	Dimensional analysis and unit conversion options
`SimFunction`	Function-like interface to execute SimBiology models
`SimFunctionSensitivity`	SimFunctionSensitivity object, subclass of `SimFunction` object
`Scenarios`	Simulation scenarios

Apps

SimBiology Model Builder	Build QSP, PK/PD, and mechanistic systems biology models interactively
SimBiology Model Analyzer	Analyze QSP, PK/PD, and mechanistic systems biology models

Examples and How To

App Workflow

Find Important Parameters with Local Sensitivity Analysis Using SimBiology Model Analyzer App
Perform sensitivity analysis to find important model parameters.

Programmatic Workflow

Calculate Sensitivities Using sbiosimulate
This example uses the model described in Model of the Yeast Heterotrimeric G Protein Cycle to illustrate SimBiology^® sensitivity analysis options.

Concepts

Sensitivity Analysis in SimBiology
Sensitivity analysis lets you explore the effects of variations in model quantities (species, compartments, and parameters) on a model response.
Model Simulation
Simulate dynamic models using various solvers.
Accelerating Model Simulations and Analyses
Accelerate the simulation or analysis by converting the model to compiled C code.